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Stephen Sinatra discusses a condition thats close to his own heart diabetes and high blood sugar

I covered the trials and the mechanism here

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Notably, this treatment increased the proportion of M1 macrophages expressing IL12 and IFN, leading to a more immunostimulatory tumor microenvironment ( Given the intratumoral heterogeneity of TAM polarization in ovarian cancer, a strategic combination of macrophage-targeted therapies, such as CSF1R and TREM2 inhibitors, with immunotherapies holds promise for improving clinical outcomes